SODIUM REDUCTION IN BOUILLON: TARGETING A FOOD STAPLE TO REDUCE HYPERTENSION IN SUB-SAHARAN AFRICA


Inhibitors of Deubiquitinating Enzymes Interfere with the SARS-CoV-2 Papain-like Protease and Block Virus Replication In Vitro

The ubiquitin proteasome system (UPS), particularly its deubiquitinating enzymes Wire Harness Kit (DUBs), play a key role in the replication cycle of coronaviruses.The SARS-CoV-2 papain-like protease (Plpro) is known to process the viral polyproteins to form the replicase transcriptase complex and to counteract the host viral response.Recently, it

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Evidence of mitochondria origin of SARS-CoV-2 double-membrane vesicles: a review. [version 2; peer review: 2 approved]

Coronavirus Disease-19 (COVID-19) pandemic is caused by SARS-CoV-2 that has infected more than 600 million people and killed more than 6 million people worldwide.This infection affects mainly certain groups of people that have high susceptibility to present severe COVID-19 due to comorbidities.Moreover, the long-COVID-19 comprises a series of sympt

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Aversion to ambiguity and willingness to take risks affect therapeutic decisions in managing atrial fibrillation for stroke prevention: results of a pilot study in family physicians

Stavroula Raptis,1,* Jia Ning Chen,2,* Florencia Saposnik,2 Roman Pelyavskyy,2 Andrew Liuni,3 Gustavo Saposnik2,4 On behalf of the Stroke Outcomes Research Canada Working Group (SORCan- www.sorcan.ca) 1Applied Health Research Centre, Li Ka Shing Knowledge Institute, 2Stroke Outcomes and Decision Neuroscience Research Unit, Department of Medicine, S

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